Strategic Plan Objective Detail
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Question 4: Short-term Objective F  

$7,575,212.03
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:

Download 2010 Question 4: Short-term Objective F projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Enhancing understanding and use of conversational rules in school-aged speakers with autism spectrum disorders Austin, Sarita Yale University
ACE Network: Early pharmacotherapy guided by biomarkers in autism Chugani, Diane Wayne State University
ACE Center: Risk and protective factors in the development of associated symptoms in autism Estes, Annette University of Washington
The mirror neuron system in children with autism Bernier, Raphael University of Washington
2/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Storch, Eric University of South Florida
3/3-Atomoxetine placebo and parent training in autism Smith, Tristram University of Rochester
2/3-Multisite RCT of early intervention for spoken communication in autism Smith, Tristram University of Rochester
The comparison of three behavioral therapy approaches for children with autism Quinn, Sheila University of Rhode Island
Evidence-based cognitive rehabilitation to improve functional outcomes for young adults with autism spectrum disorders Minshew, Nancy University of Pittsburgh
A randomized clinical trial of cognitive enhancement therapy for adults with autism spectrum disorders Minshew, Nancy University of Pittsburgh
1/3-Atomoxetine placebo and parent training in autism Handen, Benjamin University of Pittsburgh
Social cognition and interaction training for adolescents with high functioning autism Penn, David; Dichter, Gabriel University of North Carolina at Chapel Hill
Early intervention for children screened positive for autism by the First Year Inventory Baranek, Grace; Watson, Linda; Reznick, Steven; Crais, Elisabeth University of North Carolina at Chapel Hill
Predictors of effects of propranolol on language & connectivity in autism Beversdorf, David University of Missouri
3/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Ehrenreich-May, Jill University of Miami
Improving synchronization and functional connectivity in autism spectrum disorders through plasticity-induced rehabilitation training Pineda, Jaime University of California, San Diego
Prelinguistic symptoms of autism spectrum disorders in infancy Bradshaw, Jessica University of California, Los Angeles
1/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Wood, Jeffrey University of California, Los Angeles
1/3-Multisite RCT of early intervention for spoken communication in autism Kasari, Connie University of California, Los Angeles
Neurocognitive markers of response to treatment in autism Young, Gregory University of California, Davis
HCC: Collaborative research: Social-emotional technologies for autism spectrum disorders Goodwin, Matthew The Groden Center, Inc.
Integrated play groups: Promoting social communication and symbolic play with peers across settings in children with autism Wolfberg, Pamela San Francisco State University
2/3-Atomoxetine placebo and parent training in autism Aman, Michael Ohio State University
Evaluating behavioral and neural effects of social skills intervention for school-age children with autism spectrum disorders Wang, A. Ting; Soorya, Latha Mount Sinai School of Medicine
Neural and behavioral outcomes of social skills groups in children with ASD Wang, A. Ting; Soorya, Latha Mount Sinai School of Medicine

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups:
  • Five trials in infants and toddlers by 2013.

    IACC Recommended Budget: $30,000,000 over 5 years (revised in 2010)
  • Three trials in school-aged children and/or adolescents by 2013.

    IACC Recommended Budget: $18,000,000 over 5 years (revised in 2010)
  • Three trials in adults by 2014.

    IACC Recommended Budget: $18,000,000 over 5 years

Total IACC Recommended Budget: $66,000,000 over 5 years

4.3 & 4.4
$12,109,516
16 projects & 30 projects

4.S.F
$9,791,270
42 projects

4.S.F
$7,575,212
30 projects

4.S.F
$5,445,599
23 projects


4.S.F
$6,255,438
21 projects


$41,177,035
4.S.F. Funding: The recommended budget was partially met.

Progress: The investment in projects under this objective is making good progress toward the recommended amount, with more than 20 projects funded in 2011 and 2012.

Remaining Gaps, Needs, and Opportunities: Current projects in this area are restricted to small pilot studies, which are essential to establishing a foundation prior to expansion to larger scale work. Thus, increased investment in this area is important. It should be noted that most RCTs in the future will incorporate some aspect of biological signatures (thus potentially presenting a challenge to future coding of projects).