Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Presynaptic fragile X proteins Akins, Michael Brown University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Baylor College of Medicine
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory University of Pennsylvania
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua George Washington University
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles University of Illinois at Urbana Champaign
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Children's Memorial Hospital, Chicago
Allelic choice in Rett syndrome Donohoe, Mary Winifred Masterson Burke Medical Research Institute
Activity-dependent phosphorylation of MeCP2 Ebert, Daniel Harvard Medical School
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Virginia Commonwealth University
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela; Chen, Chinfei Children's Hospital Boston
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine University of California, Irvine
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao University of Massachusetts Medical School
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay University of Texas Southwestern Medical Center
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Harvard Medical School
Genotype-phenotype relationships in fragile X families Hagerman, Randi University of California, Davis
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
A longitudinal MRI study of brain development in fragile X syndrome Hazlett, Heather University of North Carolina at Chapel Hill
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Washington University in St. Louis
Development of novel diagnostics for fragile X syndrome Hosono, Seiyu JS Genetics, Inc.
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory