|Project Title||Principal Investigator||Institution|
|Neuronal populations related to deficits in social emotions and cognition in autism: A neurobiological and genomics approach||Allman, John||California Institute of Technology|
|Simons Simplex Collection Site - 1||Beaudet, Arthur||Baylor College of Medicine|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics||Beaudet, Arthur||Baylor College of Medicine|
|Simons Simplex Collection Site - 2||Bernier, Raphael||University of Washington|
|Neurobiology of sociability in a mouse model system relevant to autism||Brodkin, Edward||University of Pennsylvania|
|Identification and functional assessment of autism susceptibility genes - 1||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Genetic studies of autism susceptibility||Brzustowicz, Linda||Rutgers University|
|The role of Contactin-associated Protein-like 2 (CNTNAP2) and other novel genes in autism||Chakravarti, Aravinda||Johns Hopkins University School of Medicine|
|Genomic imbalances in autism - NIH||Christian, Susan||University of Chicago|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Boston Children's Hospital|
|Simons Simplex Collection Site - 3||Constantino, John||Washington University in St. Louis|
|Simons Simplex Collection Site - 4||Cook, Edwin||University of Illinois at Chicago|
|Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases||Courchesne, Eric||University of California, San Diego|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Simons Simplex Collection Site - 14||Deutsch, Curtis||University of Massachusetts Medical School|
|Simons Simplex Collection Site - 5||Fombonne, Eric||The Research Institute of the McGill University Health Centre|
|Simons Simplex Collection Site - 6||Geschwind, Daniel||University of California, Los Angeles|
|A system biology approach to autism genetics||Geschwind, Daniel||University of California, Los Angeles|
|Core--genomics/bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|Patient-oriented research in recessive pediatric brain diseases||Gleeson, Joseph||University of California, San Diego|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute For Medical Research|
|Gene finding - 1||Gusella, James||Massachusetts General Hospital|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Genotype-phenotype relationships in fragile X families||Hagerman, Randi||University of California, Davis|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.