|Project Title||Principal Investigator||Institution|
|Autism and the insula: Genomic and neural circuits||Allman, John||California Institute of Technology|
|Integrative genetic analysis of autistic brains||Arking, Dan||Johns Hopkins University School of Medicine|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|The role of the Rett gene, chromosone 15Q11-Q13, other genes, and epigenetics||Beaudet, Arthur||Baylor College of Medicine|
|Simons Simplex Collection Site||Bernier, Raphael||University of Washington|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Identification and functional assessment of autism susceptibility genes||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Pathway-based genetic studies of autism spectrum disorder||Bucan, Maja||University of Pennsylvania|
|Autism Genome Project||Buxbaum, Joseph||Mount Sinai School of Medicine|
|The role of contactin-associated protein-like 2 (CNTNAP2) and other novel genes in autism||Chakravarti, Aravinda||Johns Hopkins University School of Medicine|
|Genome-wide analyses of DNA methylation in autism||Chess, Andrew||Massachusetts General Hospital|
|Simons Simplex Collection Site||Cicero, Theodore||Washington University in St. Louis|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Children's Hospital Boston|
|Rutgers, The State University of New Jersey||Contract||Rutgers, The State University of New Jersey|
|Simons Simplex Collection Site||Cook, Edwin||University of Illinois at Chicago|
|Genetics of autism intermediate phenotypes||Coon, Hilary||University of Utah|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Simons Simplex Collection Site||Deutsch, Curtis||University of Massachusetts Medical School|
|Computational tools to analyze SNP data from patients with mental illness||Downey, Thomas||Partek, Inc.|
|Genomic hotspots of autism||Eichler, Evan||University of Washington|
|Simons Simplex Collection Site||Fombonne, Eric||The Research Institute of the McGill University Health Centre|
|Simons Simplex Collection Site||Geschwind, Daniel||University of California, Los Angeles|
|ACE Network: A comprehensive approach to identification of autism susceptibility genes||Geschwind, Daniel||University of California, Los Angeles|
|Core--Genomics/Bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|Identification of aberrantly methylated genes in autism: The role of advanced paternal age||Gingrich, Jay||Research Foundation for Mental Hygiene, Inc.|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.