Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$20,162,709.18
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Primate models of autism Amaral, David University of California, Davis
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Beth Israel Deaconess Medical Center
The role of SHANK3 in the etiology of autism spectrum disorder Bangash, M. Johns Hopkins University
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Transgenic mouse model to address heterogeneity in autism spectrum disorders Blakely, Randy Vanderbilt University
The genetic control of social behavior in the mouse Blanchard, Robert University of Hawai'i at Manoa
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward University of Pennsylvania
Neurobiology of sociability in a mouse model system relevant to autism (supplement) Brodkin, Edward University of Pennsylvania
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
Molecular determinants of L-type calcium channel gating Colecraft, Henry Columbia University
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health (NIH)
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Serotonin, autism, and investigating cell types for CNS disorders Dougherty, Joseph The Rockefeller University
Role of UBE3A in neocortical plasticity and function Ehlers, Michael Duke University
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela Children's Hospital Boston
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
The integration of interneurons into cortical microcircuits Fishell, Gordon New York University School of Medicine
Functional genomic dissection of language-related disorders Fisher, Simon University of Oxford
The role of CNTNAP2 in embryonic neural stem cell regulation Gaiano, Nicholas Johns Hopkins University School of Medicine
Genomic imbalances at the 22q11 locus and predisposition to autism Gogos, Joseph Columbia University
A proposal to define cells and circuits impacted in autism spectrum disorders Heintz, Nathaniel The Rockefeller University
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.

IACC Recommended Budget: $75,000,000 over 5 years
4.5
$15,879,827
42 projects

4.S.B
$20,162,709
70 projects

4.S.B
$23,229,501
92 projects

4.S.B
$21,606,118
89 projects

4.S.B
$21,232,514
94 projects

$102,110,669
4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 90 projects were supported to develop animal models.

Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built. The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.