Strategic Plan Objective Detail
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Question 4: Short-term Objective F  

$9,791,269.68
Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:

Download 2009 Question 4: Short-term Objective F projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
2/3-Atomoxetine placebo and parent training in autism Aman, Michael The Ohio State University
Enhancing understanding and use of conversational rules in school-aged speakers with autism spectrum disorders Austin, Sarita Yale University
Early intervention for children screened positive for autism by the First Year Inventory Baranek, Grace; Watson, Linda; Reznick, Steven; Crais, Elisabeth University of North Carolina at Chapel Hill
Enhancing social functioning among adolescents with Asperger's syndrome and high functioning autism Beidel, Deborah Penn State Milton S. Hershey Medical Center
The mirror neuron system in children with autism Bernier, Raphael University of Washington
Enhancing inter-subjectivity in infants at high risk for autism Bryson, Susan; Brian, Jessica; Smith, Isabel; Zwaigenbaum, Lonnie; Roberts, Wendy IWK Health Centre/Dalhousie University; University of Toronto; University of Alberta; The Hospital for Sick Children
A multi-site clinical randomized trial of the Hanen More Than Words Intervention Carter, Alice University of Massachusetts Boston
ACE Network: Early pharmacotherapy guided by biomarkers in autism Chugani, Diane Wayne State University
3/3 CBT for anxiety disorders in autism: Adapting treatment for adolescents Ehrenreich, Jill University of Miami
Intervention for infants at risk for autism Estes, Annette University of Washington
ACE Center: Risk and protective factors in the development of associated symptoms in autism Estes, Annette University of Washington
Social skills training for young adults with autism spectrum disorders Gantman, Alexander University of California, Los Angeles
1/3-Atomoxetine placebo and parent training in autism Handen, Benjamin University of Pittsburgh
High school inclusion program for students with autism spectrum disorders Hughes, Carolyn Vanderbilt University
Improving social-communication, literacy, and adaptive behaviors for young children with autism spectrum disorders Kamps, Debra University of Kansas
Joint attention intervention for caregivers and their children with autism Kasari, Connie University of California, Los Angeles
1/3-Multisite RCT of early intervention for spoken communication in autism Kasari, Connie University of California, Los Angeles
ACE Center: Optimizing social and communication outcomes for toddlers with autism Kasari, Connie University of California, Los Angeles
ACE Center: Optimizing social and communication outcomes for toddlers with autism (supplement) Kasari, Connie University of California, Los Angeles
Developmental and augmented intervention for facilitating expressive language Kasari, Connie; Kaiser, Ann; Landa, Rebecca; Murphy, Susan University of California, Los Angeles; Vanderbilt University; Kennedy Krieger Institute; University of Michigan
Promoting communication skills in toddlers at risk for autism Kasari, Connie; Sigman, Marian University of California, Los Angeles
3/3-Multisite RCT of early intervention for spoken communication in autism Landa, Rebecca Kennedy Krieger Institute
3/3-Multisite RCT of early intervention for spoken communication in autism (supplement) Landa, Rebecca Kennedy Krieger Institute
A randomized control study of relationship focused intervention with young children with ASD Mahoney, Gerald Case Western Reserve University
Efficacy and sustainability of the STAR program Mandell, David University of Pennsylvania

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Launch randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes in each of the following groups:
  • Five trials in infants and toddlers by 2013.

    IACC Recommended Budget: $30,000,000 over 5 years (revised in 2010)
  • Three trials in school-aged children and/or adolescents by 2013.

    IACC Recommended Budget: $18,000,000 over 5 years (revised in 2010)
  • Three trials in adults by 2014.

    IACC Recommended Budget: $18,000,000 over 5 years

Total IACC Recommended Budget: $66,000,000 over 5 years

4.3 & 4.4
$12,109,516
16 projects & 30 projects

4.S.F
$9,791,270
42 projects

4.S.F
$7,575,212
30 projects

4.S.F
$5,445,599
23 projects


4.S.F
$6,255,438
21 projects


$41,177,035
4.S.F. Funding: The recommended budget was partially met.

Progress: The investment in projects under this objective is making good progress toward the recommended amount, with more than 20 projects funded in 2011 and 2012.

Remaining Gaps, Needs, and Opportunities: Current projects in this area are restricted to small pilot studies, which are essential to establishing a foundation prior to expansion to larger scale work. Thus, increased investment in this area is important. It should be noted that most RCTs in the future will incorporate some aspect of biological signatures (thus potentially presenting a challenge to future coding of projects).