Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$23,229,501.04
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Patient iPS cells with copy number variations to model neuropsychiatric disorders Ellis, James The Hospital for Sick Children
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
NrCAM, a candidate susceptibility gene for visual processing deficits in autism Maness, Patricia University of North Carolina at Chapel Hill
Novel strategies to manipulate Ube3a expression for the treatment of autism and Angelman syndrome Roth, Bryan University of North Carolina at Chapel Hill
Novel probiotic therapies for autism Patterson, Paul California Institute of Technology
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Novel genetic animal models of autism Powell, Craig University of Texas Southwestern Medical Center
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. University of North Carolina School of Medicine
Neuroligin function in vivo: Implications for autism and mental retardation Powell, Craig University of Texas Southwestern Medical Center
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Duke University
Neurobiology of sociability in a mouse model system relevant to autism Brodkin, Edward University of Pennsylvania
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Massachusetts Institute of Technology
Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder Anderson, Matthew Beth Israel Deaconess Medical Center
Neural mechanisms of social cognition and bonding Young, Larry Emory University
Neural mechanisms of social cognition and bonding Young, Larry Emory University
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Murine genetic models of autism Veenstra-Vanderweele, Jeremy Vanderbilt University
Mouse genetic model of a dysregulated serotonin transporter variant associated with autism Veenstra-Vanderweele, Jeremy Vanderbilt University
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Albert Einstein College of Medicine of Yeshiva University
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Investigating the effects of chromosome 22q11.2 deletions Karayiorgou, Maria Columbia University