Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism Pozzo-Miller, Lucas University of Alabama at Birmingham
MicroRNAs in synaptic plasticity and behaviors relevant to autism Kelleher, Raymond Massachusetts General Hospital
Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome Lin, Michael Stanford University
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
Neural circuit deficits in animal models of Rett syndrome Xiong, Qiaojie Cold Spring Harbor Laboratory
Neuronal activity-dependent regulation of MeCP2 Greenberg, Michael Harvard Medical School
Neuronal activity-dependent regulation of MeCP2 (supplement) Greenberg, Michael Harvard Medical School
New approaches to local translation: SpaceSTAMP of proteins synthesized in axons Segal, Rosalind Dana-Farber Cancer Institute
Olfactory abnormalities in the modeling of Rett syndrome Ronnett, Gabriele Johns Hopkins University
Presynaptic fragile X proteins Akins, Michael Brown University
Probing a monogenic form of autism from molecules to behavior Tsien, Richard Stanford University
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela; Chen, Chinfei Children's Hospital Boston
Proteomics in drosophila to identify autism candidate substrates of UBE3A Reiter, Lawrence University of Tennessee Health Science Center
Quantitative proteomic approach towards understanding and treating autism Jin, Peng Emory University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony The George Washington University
Regulation of 22q11 genes in embryonic and adult forebrain Lamantia, Anthony University of North Carolina at Chapel Hill
Regulation of synapse elimination by FMRP Wilkerson, Julia University of Texas Southwestern Medical Center
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Washington University in St. Louis
Sex differences in early brain development; Brain development in Turner syndrome Santelli, Rebecca University of North Carolina at Chapel Hill
Study of fragile X mental retardation protein in synaptic function and plasticity Huber, Kimberly University of Texas Southwestern Medical Center
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles University of Illinois at Urbana Champaign
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Children's Memorial Hospital, Chicago
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku University of Washington
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao University of Massachusetts Medical School