Strategic Plan Objective Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Question 2: Short-term Objective G  

$9,149,672.07
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Download 2010 Question 2: Short-term Objective G projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Santangelo, Susan Massachusetts General Hospital
Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD Monk, Christopher University of Michigan
Neurogenic growth factors in autism Vaccarino, Flora Yale University
Relating copy number variants to head and brain size in neuropsychiatric disorders Sebat, Jonathan University of California, San Diego
Simons Variation in Individual Project (Simons VIP) Core Leader Gift Hanson, Ellen Children's Hospital Boston
Simons Variation in Individuals Project (Simons VIP) Lese Martin, Christa Emory University
Simons Variation in Individuals Project (Simons VIP) Core Leader Gift Sherr, Elliott University of California, San Francisco
Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift Chung, Wendy Columbia University
Simons Variation in Individuals Project (VIP) Site Bernier, Raphael University of Washington
Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates Radoeva, Petya State University of New York Upstate Medical University
Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes Webb, Sara University of Washington
The brain genomics superstruct project Buckner, Randy President & Fellows of Harvard College
The genetic basis of mid-hindbrain malformations Dobyns, William Seattle Children's Hospital
The genetic link between autism and structural cerebellar malformations Millen, Kathleen University of Chicago

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.

IACC Recommended Budget: $22,600,000 over 5 years
N/A

2.S.G
$5,903,875
21 projects

2.S.G
$9,149,672
39 projects

2.S.G
$11,105,408
45 projects

2.S.G
$15,618,073
44 projects

$41,777,028
2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.

Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.