Strategic Plan Objective Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Question 2: Short-term Objective D  

$9,171,542.17
Fiscal Year: 2009

New! Yellow dot: Objective has some degree of funding, but less than the recommended amount.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2009 Question 2: Short-term Objective D projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Coordinated control of synapse development by autism-linked genes Huber, Kimberly University of Texas Southwestern Medical Center
Developmental versus acute mechanisms mediating altered excitatory synaptic function in the fragile X syndrome mouse model Huber, Kimberly University of Texas Southwestern Medical Center
Cellular and molecular alterations in GABAergic inhibitor circuits by mutations in MeCP2 Huang, Z. Josh Cold Spring Harbor Laboratory
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
Cell type-based genomics of developmental plasticity in cortical GABA interneurons Huang, Z. Josh Cold Spring Harbor Laboratory
Genetics and physiology of social anxiety in fragile X Hessl, David University of California, Davis
A longitudinal MRI study of brain development in fragile X syndrome Hazlett, Heather Cody University of North Carolina at Chapel Hill
High content screens of neuronal development for autism research Halpain, Shelley University of California, San Diego
Fundamental mechanisms of GPR56 activation and regulation Hall, Randy Emory University
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Gibson, Jay University of Texas Southwestern Medical Center
Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome (supplement) Gibson, Jay University of Texas Southwestern Medical Center
The microRNA pathway in translational regulation of neuronal development Gao, Fen-Biao J. David Gladstone Institutes
Mouse models of the neuropathology of tuberous sclerosis complex Gambello, Michael University of Texas Health Science Center at Houston
BDNF and the restoration of spine plasticity with autism spectrum disorders Gall, Christine University of California, Irvine
Synaptic analysis of neuroligin 1 function Fuccillo, Marc Stanford University
Neuroligin regulation of central GABAergic synapses Fu, Zhanyan Duke University
Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses Engelman, Holly Albert Einstein College of Medicine of Yeshiva University
Face processing and brain function associated with autistic symptoms in fragile X Dalton, Kim University of Wisconsin - Madison
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Role of excitation and inhibition in Rett syndrome Chao, Hsiao-Tuan Baylor College of Medicine
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
Elucidation of the developmental role of JAKMIP1, an autism-susceptibility gene Bomar, Jamee University of California, Los Angeles
Chromatin alterations in Rett syndrome Akbarian, Schahram University of Massachusetts Medical School