|Project Title||Principal Investigator||Institution|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|A neuroimaging study of twin pairs with autism||Hardan, Antonio||Stanford University|
|Simons Variation in Individual Project (Simons VIP) Core Leader Gift||Hanson, Ellen||Children's Hospital Boston|
|ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition||Geschwind, Daniel||University of California, Los Angeles|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models||Dulawa, Stephanie||University of Chicago|
|Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement)||Dulawa, Stephanie||University of Chicago|
|The genetic basis of mid-hindbrain malformations||Dobyns, William||Seattle Children's Hospital|
|ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes||Cook, Edwin||University of Illinois at Chicago|
|Autistic traits: Life course & genetic structure||Constantino, John||Washington University|
|Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift||Chung, Wendy||Columbia University|
|The brain genomics superstruct project||Buckner, Randy||President & Fellows of Harvard College|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Neural and phenotypic correlates of autism risk genes||Bookheimer, Susan||University of California, Los Angeles|
|Simons Variation in Individuals Project (VIP) Site||Bernier, Raphael||University of Washington|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.