|Project Title||Principal Investigator||Institution|
|A molecular genetic study of autism and related phenotypes in extended pedigrees||Piven, Joseph||University of North Carolina at Chapel Hill|
|Simons Simplex Collection Site||Peterson, Bradley||Columbia University|
|Clinical and Bioinformatics Core (supplement)||Pericak-Vance, Margaret||Duke University|
|Molecular and genetic epidemiology of autism||Pericak-Vance, Margaret||University of Miami Miller School of Medicine|
|Molecular Analysis Core (supplement)||Pericak-Vance, Margaret||Duke University|
|Genetic studies in autism on chromosome 7 (supplement)||Pericak-Vance, Margaret||Duke University|
|Illumina, Inc.||No PI listed||Illumina, Inc.|
|Pilot project to assess web-based family recruitment for autism genetics studies||Nelson, Stan; Constantino, John; Law, Paul||University of California, Los Angeles; Washington University in St. Louis; Kennedy Krieger Institute|
|Genetic investigation of cognitive development in autistic spectrum disorders||Morrow, Eric||Brown University|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Identification and functional assessment of autism susceptibility genes||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Simons Simplex Collection Site||Miles, Judith||University of Missouri|
|Relevance of NPAS1/3 balance to autism and schizophrenia||McKnight, Steven||University of Texas Southwestern Medical Center|
|Simons Simplex Collection Site||Lord, Catherine||University of Michigan|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Simons Simplex Collection Site||Ledbetter, David||Emory University|
|Epigenetic etiologies of autism spectrum disorders||LaSalle, Janine||University of California, Davis|
|Center for Genomic and Phenomic Studies in Autism||Lajonchere, Clara||University of Southern California|
|RNA expression patterns in autism||Kunkel, Louis||Children's Hospital Boston|
|Uncovering genetic mechanisms of ASD||Kunkel, Louis||Children's Hospital Boston|
|Genomic imbalances in autism||Kumar, Ravinesh||University of Chicago|
|Simons Simplex Collection Site||Kochel, Robin||Baylor College of Medicine|
|Simons Simplex Collection Site||Klin, Ami||Yale University|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Neurogenetics of candidate systems in autism (supplement)||Haines, Jonathan||Duke University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.