Strategic Plan Objective Detail
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Question 3: Long-term Objective B  

$34,432,884.28
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2010 Question 3: Long-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Molecular and genetic epidemiology of autism Pericak-Vance, Margaret University of Miami Miller School of Medicine
Simons Simplex Collection Site Pelphrey, Kevin Yale University
Illumina, Inc. No PI listed Illumina, Inc.
Genetic investigation of cognitive development in autistic spectrum disorders Morrow, Eric Brown University
Identifying and understanding the action of autism susceptibility genes Monaco, Anthony University of Oxford
Genome-wide association study of autism characterized by developmental regression Molloy, Cynthia Cincinnati Children's Hospital Medical Center
Linking autism and congenital cerebellar malformations Millen, Kathleen University of Chicago
Simons Simplex Collection Site Miles, Judith University of Missouri
Relevance of NPAS1/3 balance to autism and schizophrenia McKnight, Steven University of Texas Southwestern Medical Center
Simons Simplex Collection Site Lord, Catherine University of Michigan
The frequency of polymorphisms in maternal- and paternal-effect genes in autism spectrum Levine, Arnold Princeton University
Simons Simplex Collection Site Lese Martin, Christa Emory University
Uncovering genetic mechanisms of ASD Kunkel, Louis Children's Hospital Boston
RNA expression patterns in autism Kunkel, Louis Children's Hospital Boston
Genomic imbalances in autism Kumar, Ravinesh University of Chicago
Simons Simplex Collection Site Kochel, Robin Baylor College of Medicine
The role of retrotransposons in autism spectrum disorders Kazazian, Haig Johns Hopkins University
The role of the neurexin 1 gene in susceptibility to autism Gusella, James Massachusetts General Hospital/Harvard Medical School
Genes disrupted by balanced genomic rearrangements in autism spectrum disorders Gusella, James Massachusetts General Hospital
A recurrent genetic cause of autism Gusella, James Massachusetts General Hospital
Dense mapping of candidate regions linked to autistic disorder Gregersen, Peter Feinstein Institute For Medical Research
Whole-genome sequencing for rare highly penetrant gene variants in schizophrenia Goldstein, David Duke University
Whole-exome sequencing to identify causative genes for autism Gleeson, Joseph University of California, San Diego
ACE Network: A comprehensive approach to identification of autism susceptibility genes Geschwind, Daniel University of California, Los Angeles
Simons Simplex Collection Site Geschwind, Daniel University of California, Los Angeles

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.