Strategic Plan Objective Detail
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Question 2: Short-term Objective A  

$4,972,407.28
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SA. Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Download 2010 Question 2: Short-term Objective A projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Influence of the maternal immune response on the development of autism Ponzio, Nicholas University of Medicine & Dentistry of New Jersey
Consequences of maternal antigen exposure on offspring immunity: An animal model of vertical tolerance Rall, Glenn The Fox Chase Cancer Center
EFRI- BSBA: Novel microsystems for manipulation and analysis of immune cells Revzin, Alexander University of California, Davis
A primate model of gut, immune, and CNS response to childhood vaccines Sackett, Gene University of Washington
Environmentally induced oxidative stress and altered local brain thyroid horomone metabolism: relevance to autism? Sajdel-Sulkowski, Elizabeth Harvard Medical School; Brigham and Women's Hospital
Mechanisms of mitochondrial dysfunction in autism Shoffner, John Georgia State University
The effect of mercury and neuropeptide triggers on human mast cell release of neurotoxic molecules Theohardies, Theoharis Tufts University
Does mercury and neurotension induce mitochondrial DNA release from human mast cells and contribute to auto-immunity in ASD? Theohardies, Theoharis Tufts University
Project 2: Immunological susceptibility of autism Van de Water, Judy University of California, Davis
A mitochondrial etiology of autism Wallace, Douglas Children's Hospital of Philadelphia