Strategic Plan Objective Detail
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Question 2: Short-term Objective G  

$9,149,672.07
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Download 2010 Question 2: Short-term Objective G projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
The genetic basis of mid-hindbrain malformations Dobyns, William Seattle Children's Hospital
Behavioral and genetic biomarker development for autism and related disorders Brzustowicz, Linda Rutgers, The State University of New Jersey - New Brunswick
The brain genomics superstruct project Buckner, Randy President & Fellows of Harvard College
A family-genetic study of language in autism Losh, Molly Northwestern University
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly Northwestern University
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Manoach, Dara Massachusetts General Hospital
Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Santangelo, Susan Massachusetts General Hospital
Characterizing the genetic systems of autism through multi-disease analysis Wall, Dennis Harvard Medical School
Language processing in children with 22q11 deletion syndrome and autism Ousley, Opal Emory University
Simons Variation in Individuals Project (Simons VIP) Lese Martin, Christa Emory University
Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift Chung, Wendy Columbia University
Functional imaging of flexibility in autism: Informed by SLC6A4 Yerys, Benjamin Children's Research Institute
Simons Variation in Individual Project (Simons VIP) Core Leader Gift Hanson, Ellen Children's Hospital Boston
Autism: The neural substrates of language in siblings Lindgren, Kristen Boston University Medical Campus

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.

IACC Recommended Budget: $22,600,000 over 5 years
N/A

2.S.G
$5,903,875
21 projects

2.S.G
$9,149,672
39 projects

2.S.G
$11,105,408
45 projects

2.S.G
$15,618,073
44 projects

$41,777,028
2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.

Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.