|Project Title||Principal Investigator||Institution|
|ACE Network: A longitudinal MRI study of infants at risk for autism||Piven, Joseph||University of North Carolina at Chapel Hill|
|Supplement to NIH ACE Network grant: "A longitudinal MRI study of infants at risk for autism"||Piven, Joseph||University of North Carolina at Chapel Hill|
|Defining high and low risk expression of emotion in infants at risk for autism||Hannigen, Sarah||University of Pittsburgh|
|Temporal coordination of social communicative behaviors in infant siblings of children with autism||Parlade, Meaghan||University of Pittsburgh|
|Early identification of autism: A prospective study||Iverson, Jana||University of Pittsburgh|
|Early social and emotional development in toddlers at genetic risk for autism||Campbell, Susan||University of Pittsburgh|
|Observational and electrophysiological assessments of temperament in infants at risk for autism spectrum disorders||Burner, Karen||University of Washington|
|Neurophysiological indices of risk and outcome in autism||Webb, Sara||University of Washington|
|ACE Center: Linguistic and social responses to speech in infants at risk for autism||Kuhl, Patricia||University of Washington|
|A longitudinal 3-D MRSI study of infants at high risk for autism||Dager, Stephen||University of Washington|
|Developmental characteristics of MRI diffusion tensor pathway changes in autism||Conturo, Thomas||Washington University|
|Misregulation of BDNF in autism spectrum disorders||Hempstead, Barbara||Weill Cornell Medical College|
|Biomarkers for autism and for gastrointestinal and sleep problems in autism||Anderson, George||Yale University|
|Prospective study of infants at high risk for autism||Chawarska, Katarzyna||Yale University|
|The ontogeny of social visual engagement in infants at risk for autism||Klin, Ami||Yale University|
|ACE Center: Gaze perception abnormalities in infants with ASD||Chawarska, Katarzyna||Yale University|
|ACE Center: Assessment Core||Klin, Ami||Yale University|
|Physical and clinical infrastructure for research on infants-at-risk for autism at Yale||Klin, Ami||Yale University|
|Model diagnostic lab for infants at risk for autism||Klin, Ami||Yale University|
|Brain-behavior growth charts of altered social engagement in ASD infants||Klin, Ami||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD, and evaluate whether these risk markers or profiles can improve early identification through heightened developmental monitoring and screening by 2014.
IACC Recommended Budget: $33,300,000 over 5 years
|1.L.A. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 40 projects have been supported in this area, but most projects are still in the discovery phase. Identifying reliable early biomarkers has been challenging, but some progress has been made. More work is needed to achieve the full intent of the objective.
Remaining Gaps, Needs, and Opportunities: Remaining research needs include continued discovery of biomarkers, linking biomarkers to treatment response, validation of biomarkers discovered in high risk populations for applicability in the general population, and evaluation of whether these biomarkers translate to improvement in screening and diagnosis real-world settings. There is also a need for biomarkers that are cost-effective.