|Project Title||Principal Investigator||Institution|
|ACE Center: The development of the siblings of children with autism: A longitudinal study||Sigman, Marian||University of California, Los Angeles|
|Neuroimaging & symptom domains in autism||Levitt, Jennifer||University of California, Los Angeles|
|Magnetic source imaging and sensory behavioral characterization in autism||Marco, Elysa||University of California, San Francisco|
|Child-initiated communicative interactions and autism intervention||Koegel, Robert||University of California, Santa Barbara|
|Child-initiated communicative interactions and autism intervention (supplement)||Koegel, Robert||University of California, Santa Barbara|
|Emotional mimicry in children with autism||Moody, Eric||University of Colorado Denver|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Forsyth, David||University of Illinois at Urbana-Champaign|
|Emotion, communication, & EEG: Development & risk||Messinger, Daniel||University of Miami|
|Automated measurement of facial expression in autism: Deficits in facial nerve function?||Messinger, Daniel||University of Miami|
|Neural mechanisms underlying obsessive compulsiveness in ASD||Carrasco, Melisa||University of Michigan|
|Collaborative research: Computational behavioral science: Modeling, analysis, and visualization of social and communicative behavior||Narayanan, Shrikanth||University of Southern California|
|Family studies of sensorimotor and neurocognitive heterogeneity in autism spectrum disorders (ASD)||Sweeney, John||University of Texas Southwestern Medical Center at Dallas|
|ACE Center: Early detection and intervention in infants at risk for autism||Dawson, Geraldine||University of Washington|
|Social-emotional development of infants at risk for autism spectrum disorders||Stone, Wendy; Messinger, Daniel||University of Washington|
|Amygdala structure & biochemistry in adolescents with autism||Nacewicz, Brendon||University of Wisconsin - Madison|
|Predicting useful speech in children with autism||Yoder, Paul||Vanderbilt University|
|Ethnicity and the elucidation of autism endophenotypes||Constantino, John||Washington University in St. Louis|
|The intersection of autism and ADHD||Reiersen, Angela||Washington University in St. Louis|
|Development of face processing in infants with autism spectrum disorders||Chawarska, Katarzyna||Yale University|
|CDI-Type I: Understanding regulation of visual attention in autism through computational and robotic modeling||Scassellati, Brian||Yale University|
|Social evaluation in infants and toddlers||Wynn, Karen||Yale University|
|Extraction of functional subnetworks in autism using multimodal MRI||Duncan, James; Syaib, Lawrence; Pelphrey, Kevin||Yale University|
|Perception of social and physical contingencies in infants with ASD||Klin, Ami||Yale University|
|Performance indices of social disability in toddlers with autism (supplement)||Klin, Ami||Yale University|
|ACE Center: Eye-tracking studies of social engagement||Klin, Ami||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015.
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met.
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.