|Project Title||Principal Investigator||Institution|
|Prostaglandins and cerebellum development||McCarthy, Margaret||University of Maryland, Baltimore|
|Influence of maternal cytokines on activation of the innate immune system as a factor in the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of maternal cytokines during pregnancy on effector and regulatory T helper cells as etiological factors in autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Influence of the maternal immune response on the development of autism||Ponzio, Nicholas||University of Medicine & Dentistry of New Jersey|
|Molecular pathways involved in oxidative stress and leaky gut impairment in autism spectrum disorders||Antonucci, Nicola||University of Naples|
|Study of anti-neuronal autoantibodies in behavioral and movement disorders||Cunningham, Madeleine||University of Oklahoma Health Sciences Center|
|CNS toxicity of ambient air pollution: Postnatal exposure to ultrafine particles||Cory-Slechta, Deborah||University of Rochester|
|Redox abnormalities as a vulnerability phenotype for autism and related alterations in CNS development||Noble, Mark||University of Rochester|
|An ex-vivo placental perfusion system to study materno-fetal biology||Bonnin, Alexandre||University of Southern California|
|Neurological diseases due to inborn errors of metabolism||Pascual, Juan||University of Texas Southwestern Medical Center|
|A primate model of gut, immune, and CNS response to childhood vaccines||Sackett, Gene||University of Washington|
|Systematic characterization of the immune response to gluten and casein in autism spectrum disorders||Alaedini, Armin||Weill Cornell Medical College|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010 (Fever studies to be started by 2012).
IACC Recommended Budget: $9,800,000 over 4 years
|2.S.A. Funding: The recommended budget for this objective was met.
Progress: Many projects were funded in this area (approximately 20-30 per year), but the field is still developing, and emphasis on this objective should continue in the future. Scientific advances have been made in linking maternal innate immune function and immune-system challenge to aspects of ASD. Methodological advances in the field include the development of animal models for study of the role of the immune system in ASD and PET ligands for imaging microglial activation.
Remaining Gaps, Needs and Opportunities: There is a need for a well-designed, multi-site clinical study of clinical effects of fever and to develop standard measures of fever and behavioral/cognitive outcomes. Questions about fever could be integrated into funded epidemiological studies. There is also interest in further work on metabolic and mitochondrial issues, but in order for this work to be done, there is a need for validation and standardization of measures for assessment of oxidative stress and mitochondrial function. More guidance is needed on the key questions for this field to answer â a workshop to define these methodologies may be helpful. One of the key questions is to determine whether it is the body temperature associated with fever or some consequence of immune activation and production of the febrile state that leads to amelioration of cognitive function.