|Project Title||Principal Investigator||Institution|
|Autism: Neuropeptide hormones and potential pathway genes (supplement)||Jacob, Suma||University of Illinois at Chicago|
|Autism: Neuropeptide hormones and potential pathway genes||Jacob, Suma||University of Illinois at Chicago|
|fMRI evidence of genetic influence on rigidity in ASD||Lee, Jillian||University of Michigan|
|Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD||Monk, Christopher||University of Michigan|
|An investigation of the overlap of autism and fragile X syndrome||Martin, Gary||University of North Carolina at Chapel Hill|
|A multigenerational longitudinal study of language development: Insight from autism||Losh, Molly||University of North Carolina at Chapel Hill|
|A family-genetic study of language in autism||Losh, Molly||University of North Carolina at Chapel Hill|
|Neural circuitry of social cognition in the broad autism phenotype||Piven, Joseph||University of North Carolina at Chapel Hill|
|Simons Variation in Individuals Project (VIP) Site||Bernier, Raphael||University of Washington|
|Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes||Webb, Sara||University of Washington|
|ACE Center: Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Autistic traits: Life course & genetic structure||Constantino, John||Washington University|
|Neurogenic growth factors in autism||Vaccarino, Flora||Yale University|
|Longitudinal neurogenetics of atypical social brain development in autism||Pelphrey, Kevin||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.
IACC Recommended Budget: $22,600,000 over 5 years
|2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.
Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.