Strategic Plan Objective Detail
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Question 2: Short-term Objective G  

$9,149,672.07
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Download 2010 Question 2: Short-term Objective G projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes Cook, Edwin University of Illinois at Chicago
Autism: Neuropeptide hormones and potential pathway genes Jacob, Suma University of Illinois at Chicago
Neural correlates of serotonin transporter gene polymorphisms and social impairment in ASD Monk, Christopher University of Michigan
fMRI evidence of genetic influence on rigidity in ASD Lee, Jillian University of Michigan
A family-genetic study of language in autism Losh, Molly University of North Carolina at Chapel Hill
A multigenerational longitudinal study of language development: Insight from autism Losh, Molly University of North Carolina at Chapel Hill
An investigation of the overlap of autism and fragile X syndrome Martin, Gary University of North Carolina at Chapel Hill
Neural circuitry of social cognition in the broad autism phenotype Piven, Joseph University of North Carolina at Chapel Hill
Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral endophenotypes Webb, Sara University of Washington
Simons Variation in Individuals Project (VIP) Site Bernier, Raphael University of Washington
ACE Center: Genetic contributions to endophenotypes of autism Wijsman, Ellen University of Washington
Autistic traits: Life course & genetic structure Constantino, John Washington University
Neurogenic growth factors in autism Vaccarino, Flora Yale University
Longitudinal neurogenetics of atypical social brain development in autism Pelphrey, Kevin Yale University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015.

IACC Recommended Budget: $22,600,000 over 5 years
N/A

2.S.G
$5,903,875
21 projects

2.S.G
$9,149,672
39 projects

2.S.G
$11,105,408
45 projects

2.S.G
$15,618,073
44 projects

$41,777,028
2.S.G. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Over 40 projects have been funded in this area, and the projects cover the areas described, so the objective appears to be on track.

Remaining Gaps, Needs and Opportunities: With so many studies initiated, the next step is to encourage multi-site collaboration in order to achieve the large number of subjects required for meaningful data interpretation.