|Project Title||Principal Investigator||Institution|
|Comprehensive genetic variation detection to assess the role of the X chromosome in autism||Warren, Stephen||Emory University|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|Simons Simplex Collection Site||Ledbetter, David||Emory University|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute for Medical Research|
|Research Center for the Study of Gene Structure and Function (supplement)||Raab, Jennifer||Hunter College|
|Illumina, Inc.||No PI listed||Illumina, Inc.|
|Understanding glutamate signaling defects in autism spectrum disorders||Wang, Tao||Johns Hopkins University|
|Integrative genetic analysis of autistic brains||Arking, Dan||Johns Hopkins University School of Medicine|
|The role of contactin-associated protein-like 2 (CNTNAP2) and other novel genes in autism||Chakravarti, Aravinda||Johns Hopkins University School of Medicine|
|Genome-wide analyses of DNA methylation in autism||Chess, Andrew||Massachusetts General Hospital|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Investigation of genes involved in synaptic plasticity in Iranian families with ASD||Santangelo, Susan||Massachusetts General Hospital|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Genes disrupted by balanced genomic rearrangements in autism spectrum disorders||Gusella, James||Massachusetts General Hospital|
|Role of TSC/mTOR signaling pathway in autism and autism spectrum disorders||Ramesh, Vijaya||Massachusetts General Hospital|
|The role of the neurexin 1 gene in susceptibility to autism||Gusella, James||Massachusetts General Hospital/Harvard Medical School|
|Autism Genome Project||Buxbaum, Joseph||Mount Sinai School of Medicine|
|Computational tools to analyze SNP data from patients with mental illness||Downey, Thomas||Partek, Inc.|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Identification of aberrantly methylated genes in autism: The role of advanced paternal age||Gingrich, Jay||Research Foundation for Mental Hygiene, Inc.|
|Rutgers, The State University of New Jersey||Contract||Rutgers, The State University of New Jersey|
|Behavioral and genetic biomarker development for autism and related disorders||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|Identification and functional assessment of autism susceptibility genes||Brzustowicz, Linda||Rutgers, The State University of New Jersey - New Brunswick|
|The impact of autism specific genomic variations on microRNA gene expression profile||Scherer, Stephen||The Hospital for Sick Children|
|Identification and functional assessment of autism susceptibility genes||Vieland, Veronica||The Research Institute at Nationwide Children's Hospital|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.