Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$23,229,501.04
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Investigation of the role of MET kinase in autism Dawson, Ted Johns Hopkins University School of Medicine
Control of synaptic protein synthesis in the pathogenesis and therapy of autism Kelleher, Raymond Massachusetts General Hospital
Neurobiology of mouse models for human chr 16p11.2 microdeletion and fragile X Bear, Mark Massachusetts Institute of Technology
Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders Bear, Mark Massachusetts Institute of Technology
Mice lacking Shank postsynaptic scaffolds as an animal model of autism Sheng, Morgan Massachusetts Institute of Technology
Neural and cognitive mechanisms of autism Sur, Mriganka Massachusetts Institute of Technology
Dissecting the circuitry basis of autistic-like behaviors in mice Feng, Guoping Massachusetts Institute of Technology
Synaptic and circuitry mechanisms of repetitive behaviors in autism Feng, Guoping Massachusetts Institute of Technology
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
Genetic models of serotonin transporter regulation linked to mental disorders Ramamoorthy, Sammanda Medical University of South Carolina
The role of SHANK3 in autism spectrum disorders Buxbaum, Joseph Mount Sinai School of Medicine
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Regulation of gene expression in the brain Young, Walter National Institutes of Health
Synaptic plasticity, memory and social behavior Chevere-Torres, Itzamarie New York University
Methods for production of ICSI and SCNT derived macaque stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Optimization of methods for production of both ICSI- and SCNT derived baboon embryonic stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Micro-RNA regulation in pluripotent stem cells Schatten, Gerald Southwest Foundation For Biomedical Research
Using iPS cells to study genetically defined forms with autism Dolmetsch, Ricardo Stanford University
Using induced pluripotent stem cells to identify cellular phenotypes of autism Dolmetsch, Ricardo Stanford University
Exploring the neuronal phenotype of autism spectrum disorders using induced pluripotent stem cells Hallmayer, Joachim; Dolmetsch, Ricardo Stanford University
Synaptic deficits of iPS cell-derived neurons from patients with autism Mao, Rong Stanford University
Function and dysfunction of neuroligins Sudhof, Thomas Stanford University
Identification of autism genes that regulate synaptic Nrx/Nlg signaling complexes Garner, Craig Stanford University
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University