|Project Title||Principal Investigator||Institution|
|Plasticity in autism spectrum disorders: Magnetic stimulation studies||Oberman, Lindsay||Beth Israel Deaconess Medical Center|
|Electrophysiological signatures of language impairment in autism spectrum disorder||Roberts, Timothy||Children's Hospital of Philadelphia|
|Electrophysiological signatures of language impairment in autism spectrum disorder (supplement)||Roberts, Timothy||Children's Hospital of Philadelphia|
|Reward systems in children with autism||Scott, Ashley||University of California, Los Angeles|
|Clinical and behavioral phenotyping of autism and related disorders||Swedo, Susan||National Institutes of Health (NIH)|
|Temperament, emotional expression, and emotional self-regulation in relation to later ASD diagnosis||Wozniak, Robert||Bryn Mawr College|
|Social evaluation in infants and toddlers||Wynn, Karen||Yale University|
|Predicting useful speech in children with autism||Yoder, Paul||Vanderbilt University|
|Predicting useful speech in children with autism (supplement)||Yoder, Paul||Vanderbilt University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. |
IACC Recommended Budget: $71,100,000 over 5 years
|1.L.B. Funding: The recommended budget was partially met. |
Progress: Over 50 projects were supported in this area. While behavioral and/or biological heterogeneity are well covered by existing projects, gaps still exist in relating these measures to etiology and risk, treatment response, and/or outcomes.
Remaining Gaps, Needs, and Opportunities: There was a discussion of whether this objective should be expanded to be compatible with the Research Domain Criteria (RDoC) now being used by NIMH, which focus on functional domains rather than disorder-specific characteristics.