|Project Title||Principal Investigator||Institution|
|Neurogenetics of candidate systems in autism||Haines, Jonathan||Duke University|
|A California population-based twin study of autism||Hallmayer, Joachim||Stanford University|
|Neurogenomics in a model for procedural learning||Hilliard, Austin||University of California, Los Angeles|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Genetic study of restricted repetitive behavior in autism spectrum disorders||Kim, Soo-Jeong||University of Florida|
|Simons Simplex Collection Site - 7||Klin, Ami||Yale University|
|Genomic imbalances in autism - AS||Kumar, Ravinesh||University of Chicago|
|Uncovering genetic mechanisms of ASD||Kunkel, Louis||Boston Children's Hospital|
|Center for genomic and phenomic studies in autism||Lajonchere, Clara||University of Southern California|
|Autism Genetic Resource Exchange (AGRE)||Lajonchere, Clara||Autism Speaks|
|The role of MECP2 in Rett syndrome||LaSalle, Janine||University of California, Davis|
|Epigenetic etiologies of autism spectrum disorders||LaSalle, Janine||University of California, Davis|
|The role of MECP2 in Rett syndrome - Supplement||LaSalle, Janine||University of California, Davis|
|Simons Simplex Collection Site - 8||Ledbetter, David||Emory University|
|Autism and SNPs in the IGF pathway||Levine, Arnold||Princeton University|
|Simons Simplex Collection Site - 9||Lord, Catherine||University of Michigan|
|Simons Simplex Collection Site - 10||Miles, Judith||University of Missouri|
|Identification and functional assessment of autism susceptibity genes - 2||Millonig, James||University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School|
|Identifying and understanding the action of autism susceptibility genes||Monaco, Anthony||University of Oxford|
|Translational genetic studies in familial ASDs||Morrow, Eric||Massachusetts General Hospital|
|Chromatin remodeling and neuronal differentiation||Pazin, Michael||National Institutes of Health|
|Genetic studies in autism on chromosome 7||Pericak-Vance, Margaret||Duke University|
|Clinical and bioinformatics core||Pericak-Vance, Margaret||Duke University|
|Molecular analysis core||Pericak-Vance, Margaret||Duke University|
|Simons Simplex Collection Site - 11||Peterson, Bradley||Columbia University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.