Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

$20,162,709.18
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2009 Question 4: Short-term Objective B projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
A comparative developmental connectivity study of face processing Joseph, Jane University of Kentucky
Neurexin-neuroligin trans-synaptic interaction in learning and memory Kandel, Eric Columbia University
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat University of Southern California
The genetics of restricted, repetitive behavior: An inbred mouse model Lewis, Mark University of Florida
Serotonin, corpus callosum, and autism Lin, Rick University of Mississippi Medical Center
Using Drosophila to model the synaptic function of the autism-linked NHE9 Littleton, J. Troy Massachusetts Institute of Technology
Neuropharmacology of motivation and reinforcement in mouse models of autistic spectrum disorders Malanga, C.J. University of North Carolina School of Medicine
Modeling and pharmacologic treatment of autism spectrum disorders in Drosophila McDonald, Thomas Albert Einstein College of Medicine of Yeshiva University
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School
Novel models to define the genetic basis of autism Mills, Alea Cold Spring Harbor Laboratory
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl University of North Carolina at Chapel Hill
Systematic analysis of neural circuitry in mouse models of autism Osten, Pavel Cold Spring Harbor Laboratory
Role of L-type calcium channels in hippocampal neuronal network activity Owen, Scott Stanford University
Dysregulation of PI3K/AKT in social interaction deficits and autism spectrum disorders with macrocephaly Parada, Luis University of Texas Southwestern Medical Center
Behavioral, physiological & neuroanatomical consequences of maternal separation Parr, Lisa Emory University
Behavioral and neural processing of faces and expressions in nonhuman primates Parr, Lisa Emory University
A non-human primate autism model based on maternal immune activation Patterson, Paul University of California, Davis
Neurogenetic model of social behavior heterogeneity in autism spectrum disorders Platt, Michael Duke University
Novel genetic animal models of autism Powell, Craig University of Texas Southwestern Medical Center
Animal models of autism: Pathogenesis and treatment Powell, Craig University of Texas Southwestern Medical Center
Role of a novel Wnt pathway in autism spectrum disorders Reichardt, Louis University of California, San Francisco
Role of Wnt signaling in forebrain development, synaptic physiology, and mouse behavior Reichardt, Louis University of California, San Francisco
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Yale University
Perturbed activity-dependent plasticity mechanisms in autism Sabatini, Bernardo Harvard Medical School

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.

IACC Recommended Budget: $75,000,000 over 5 years
4.5
$15,879,827
42 projects

4.S.B
$20,162,709
70 projects

4.S.B
$23,229,501
92 projects

4.S.B
$21,606,118
89 projects

4.S.B
$21,232,514
94 projects

$102,110,669
4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: More than 90 projects were supported to develop animal models.

Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built. The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.