|Project Title||Principal Investigator||Institution|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute For Medical Research|
|Comprehensive genetic variation detection to assess the role of the X chromosome in autism||Warren, Stephen||Emory University|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Autism Genome Project (AGP)||Staff Member||Autism Speaks (AS)|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Analysis of candidate genes derived from a protein interaction network in SSC samples||Zoghbi, Huda||Baylor College of Medicine|
|A genome-wide search for autism genes in the Simons Simplex Collection||State, Matthew||Yale University|
|ACE Network: A comprehensive approach to identification of autism susceptibility genes||Geschwind, Daniel||University of California, Los Angeles|
|ACE Center: Targeting genetic pathways for brain overgrowth in autism spectrum disorders||Wynshaw-Boris, Anthony||University of California, San Diego|
|ACE Center: Rare variant genetics, contactin-related proteins and autism||State, Matthew||Yale University|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.