Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Synaptic phenotype, development, and plasticity in the fragile X mouse Cox, Charles University of Illinois at Urbana Champaign
Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome Corbin, Joshua George Washington University
Molecular basis of autism associated with human adenylosuccinate lyase gene defects Colman, Roberta University of Delaware
Functional circuit disorders of sensory cortex in ASD and RTT Carlson, Gregory University of Pennsylvania
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Baylor College of Medicine
Presynaptic fragile X proteins Akins, Michael Brown University