Strategic Plan Objective Detail
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Question 3: Objective 8  

$37,043,409.82
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2008 Question 3: Objective 8 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Uncovering genetic mechanisms of ASD Kunkel, Louis Boston Children's Hospital
Genomic imbalances in autism - AS Kumar, Ravinesh University of Chicago
Simons Simplex Collection Site - 7 Klin, Ami Yale University
Genetic study of restricted repetitive behavior in autism spectrum disorders Kim, Soo-Jeong University of Florida
Genetic dissection of restricted repetitive behavior (RRB) Kim, Soo-Jeong University of Florida
Neurogenomics in a model for procedural learning Hilliard, Austin University of California, Los Angeles
A California population-based twin study of autism Hallmayer, Joachim Stanford University
Neurogenetics of candidate systems in autism Haines, Jonathan Duke University
Genotype-phenotype relationships in fragile X families Hagerman, Randi University of California, Davis
A recurrent genetic cause of autism Gusella, James Massachusetts General Hospital
Gene finding - 1 Gusella, James Massachusetts General Hospital
Dense mapping of candidate regions linked to autistic disorder Gregersen, Peter Feinstein Institute For Medical Research
Patient-oriented research in recessive pediatric brain diseases Gleeson, Joseph University of California, San Diego
Core--genomics/bioinformatics--Alzheimer's disease and autism Gilliam, Thomas Columbia University
A system biology approach to autism genetics Geschwind, Daniel University of California, Los Angeles
Simons Simplex Collection Site - 6 Geschwind, Daniel University of California, Los Angeles
Simons Simplex Collection Site - 5 Fombonne, Eric The Research Institute of the McGill University Health Centre
Simons Simplex Collection Site - 14 Deutsch, Curtis University of Massachusetts Medical School
Comprehensive follow-up of novel autism genetic discoveries Daly, Mark Massachusetts General Hospital
Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases Courchesne, Eric University of California, San Diego
Simons Simplex Collection Site - 4 Cook, Edwin University of Illinois at Chicago
Simons Simplex Collection Site - 3 Constantino, John Washington University in St. Louis
Gene expression profiling of autism spectrum disorders Collins, Christin Boston Children's Hospital
Genomic imbalances in autism - NIH Christian, Susan University of Chicago
The role of Contactin-associated Protein-like 2 (CNTNAP2) and other novel genes in autism Chakravarti, Aravinda Johns Hopkins University School of Medicine

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.