|Project Title||Principal Investigator||Institution|
|Uncovering genetic mechanisms of ASD||Kunkel, Louis||Boston Children's Hospital|
|Genomic imbalances in autism - AS||Kumar, Ravinesh||University of Chicago|
|Simons Simplex Collection Site - 7||Klin, Ami||Yale University|
|Genetic study of restricted repetitive behavior in autism spectrum disorders||Kim, Soo-Jeong||University of Florida|
|Genetic dissection of restricted repetitive behavior (RRB)||Kim, Soo-Jeong||University of Florida|
|Neurogenomics in a model for procedural learning||Hilliard, Austin||University of California, Los Angeles|
|A California population-based twin study of autism||Hallmayer, Joachim||Stanford University|
|Neurogenetics of candidate systems in autism||Haines, Jonathan||Duke University|
|Genotype-phenotype relationships in fragile X families||Hagerman, Randi||University of California, Davis|
|A recurrent genetic cause of autism||Gusella, James||Massachusetts General Hospital|
|Gene finding - 1||Gusella, James||Massachusetts General Hospital|
|Dense mapping of candidate regions linked to autistic disorder||Gregersen, Peter||Feinstein Institute For Medical Research|
|Patient-oriented research in recessive pediatric brain diseases||Gleeson, Joseph||University of California, San Diego|
|Core--genomics/bioinformatics--Alzheimer's disease and autism||Gilliam, Thomas||Columbia University|
|A system biology approach to autism genetics||Geschwind, Daniel||University of California, Los Angeles|
|Simons Simplex Collection Site - 6||Geschwind, Daniel||University of California, Los Angeles|
|Simons Simplex Collection Site - 5||Fombonne, Eric||The Research Institute of the McGill University Health Centre|
|Simons Simplex Collection Site - 14||Deutsch, Curtis||University of Massachusetts Medical School|
|Comprehensive follow-up of novel autism genetic discoveries||Daly, Mark||Massachusetts General Hospital|
|Demonstration of the novel RASL/DASL method for analysis of gene expression in frontal cortex in autism and control cases||Courchesne, Eric||University of California, San Diego|
|Simons Simplex Collection Site - 4||Cook, Edwin||University of Illinois at Chicago|
|Simons Simplex Collection Site - 3||Constantino, John||Washington University in St. Louis|
|Gene expression profiling of autism spectrum disorders||Collins, Christin||Boston Children's Hospital|
|Genomic imbalances in autism - NIH||Christian, Susan||University of Chicago|
|The role of Contactin-associated Protein-like 2 (CNTNAP2) and other novel genes in autism||Chakravarti, Aravinda||Johns Hopkins University School of Medicine|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.