|Project Title||Principal Investigator||Institution|
|The integration of interneurons into cortical microcircuits||Fishell, Gordon||New York University School of Medicine|
|Synaptic and circuitry mechanisms of repetitive behaviors in autism||Feng, Guoping||Massachusetts Institute of Technology|
|Probing disrupted cortico-thalamic interactions in autism spectrum disorders||Fagiolini, Michela||Children's Hospital Boston|
|Role of UBE3A in neocortical plasticity and function||Ehlers, Michael||Duke University|
|Serotonin, autism, and investigating cell types for CNS disorders||Dougherty, Joseph||The Rockefeller University|
|Using iPS cells to study genetically defined forms with autism||Dolmetsch, Ricardo||Stanford University|
|Investigation of the role of MET kinase in autism||Dawson, Ted||Johns Hopkins University School of Medicine|
|Animal models of neuropsychiatric disorders||Crawley, Jacqueline||National Institutes of Health (NIH)|
|Molecular determinants of L-type calcium channel gating||Colecraft, Henry||Columbia University|
|Synaptic plasticity, memory and social behavior||Chevere-Torres, Itzamarie||New York University|
|A preclinical model for determining the role of AVPR1A in autism spectrum disorders||Charles, Rhonda||Mount Sinai School of Medicine|
|The role of SHANK3 in autism spectrum disorders||Buxbaum, Joseph||Mount Sinai School of Medicine|
|Neurobiology of sociability in a mouse model system relevant to autism||Brodkin, Edward||University of Pennsylvania|
|Neurobiology of sociability in a mouse model system relevant to autism (supplement)||Brodkin, Edward||University of Pennsylvania|
|The genetic control of social behavior in the mouse||Blanchard, Robert||University of Hawai'i at Manoa|
|Transgenic mouse model to address heterogeneity in autism spectrum disorders||Blakely, Randy||Vanderbilt University|
|Development of a high-content neuronal assay to screen therapeutics for the treatment of cognitive dysfunction in autism spectrum disorders||Bear, Mark||Massachusetts Institute of Technology|
|The role of SHANK3 in the etiology of autism spectrum disorder||Bangash, M.||Johns Hopkins University|
|Neurobiological mechanism of 15q11-13 duplication autism spectrum disorder||Anderson, Matthew||Beth Israel Deaconess Medical Center|
|Primate models of autism||Amaral, David||University of California, Davis|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012.
IACC Recommended Budget: $75,000,000 over 5 years
|4.S.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: More than 90 projects were supported to develop animal models.
Remaining Gaps, Needs, and Opportunities: Planning Group members discussed whether the amount of investment in this area is appropriate when compared to investments in clinical trials and other later stage studies. Invited experts suggested that the current stage of scientific research in ASD requires pre-clinical research to identify targets from animal and cellular models. Similar to cancer treatment development pathways, which spanned 20-30 years, research in ASD must invest in model systems to understand the fundamental biology from which translation to the clinic can be built. The translational validity of research in non-human animals cannot be determined until human trials are conducted, thus the need for rapid progress to clinical studies in humans is important.