Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Cell-based genomic analysis in mouse models of Rett syndrome Huang, Z. Josh Cold Spring Harbor Laboratory
The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism DiDonato, Christine Children's Memorial Hospital, Chicago
Visual system connectivity in a high-risk model of autism Sahin, Mustafa Children's Hospital Boston
Probing disrupted cortico-thalamic interactions in autism spectrum disorders Fagiolini, Michela; Chen, Chinfei Children's Hospital Boston
Presynaptic fragile X proteins Akins, Michael Brown University
In-vivo imaging of neuronal structure and function in a reversible mouse model for autism. Ash, Ryan Baylor College of Medicine
Elucidating the roles of SHANK3 and FXR in the autism interactome Zoghbi, Huda Baylor College of Medicine