Strategic Plan Objective Detail
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Question 2: Short-term Objective D  

$13,162,905.00
Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Download 2010 Question 2: Short-term Objective D projects (EXCEL)
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Project Title Principal Investigator Institution
Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions Parada, Luis University of Texas Southwestern Medical Center
The mechanism and significance of Evf ncRNA regulation of the DLX genes Kohtz, Jhumku University of Washington
Genetic and developmental analyses of fragile X syndrome Broadie, Kendal Vanderbilt University
Establishing zebrafish as a model for RAI1 gene dosage Elsea, Sarah; Lister, James Virginia Commonwealth University
The role of intracellular metabotropic glutamate receptor 5 at the synapse Hogan, Carolyn Washington University in St. Louis
Role of intracellular mGluR5 in fragile X syndrome and autism O'Malley, Karen Washington University in St. Louis
Allelic choice in Rett syndrome Donohoe, Mary Winifred Masterson Burke Medical Research Institute