Strategic Plan Objective Detail
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Question 4: Short-term Objective B  

Fiscal Year: 2010

Green dot: Objective has greater than or equal to the recommended funding.4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Download 2010 Question 4: Short-term Objective B projects (EXCEL)
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Project Title Principal Investigator Institution
Characterization of autism susceptibility genes on chromosome 15q11-13 Smith, Stephen Beth Israel Deaconess Medical Center
Characterization of a novel mouse model of restricted repetitive behaviors Moy, Sheryl University of North Carolina at Chapel Hill
Central vasopressin receptors and affiliation Young, Larry Emory University
Central vasopressin receptors and affiliation Young, Larry Emory University
Cellular and genetic correlates of increased head size in autism spectrum disorder Vaccarino, Flora Yale University
Caspr2 dysfunction in autism spectrum disorders Robbins, Elissa Yale University
Behavioral and physiological consequences of disrupted Met signaling Levitt, Pat University of Southern California
Basal ganglia circuitry and molecules in pathogenesis of motor stereotypy Yang, Xiangdong University of California, Los Angeles
Autism iPSCs for studying function and dysfunction in human neural development Loring, Jeanne The Scripps Research Institute
A preclinical model for determining the role of AVPR1A in autism spectrum disorders Charles, Rhonda Mount Sinai School of Medicine
A novel cell-based assay for autism research and drug discovery Restifo, Linda University of Arizona
Animal models of neuropsychiatric disorders Crawley, Jacqueline National Institutes of Health
Animal models of autism: Pathogenesis and treatment Powell, Craig University of Texas Southwestern Medical Center
Animal model of speech sound processing in autism Kilgard, Michael University of Texas at Dallas
Analysis of cortical circuits related to ASD gene candidates Zador, Anthony Cold Spring Harbor Laboratory
A mouse knock-in model for ENGRAILED 2 autism susceptibility Millonig, James University of Medicine & Dentistry of New Jersey
16p11.2: defining the gene(s) responsible Mills, Alea Cold Spring Harbor Laboratory