Strategic Plan Objective Detail
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Question 3: Objective 8  

$37,043,409.82
Fiscal Year: 2008

Green dot: Objective has greater than or equal to the recommended funding.3.8 Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Download 2008 Question 3: Objective 8 projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
The role of MECP2 in Rett syndrome LaSalle, Janine University of California, Davis
The role of MECP2 in Rett syndrome - Supplement LaSalle, Janine University of California, Davis
The role of the Rett gene, chromosome 15q11-q13, other genes, and epigenetics Beaudet, Arthur Baylor College of Medicine
Translational genetic studies in familial ASDs Morrow, Eric Massachusetts General Hospital
Uncovering genetic mechanisms of ASD Kunkel, Louis Boston Children's Hospital
Understanding glutamate signaling defects in autism spectrum disorders Wang, Tao Johns Hopkins University
Unraveling the genetic etiology of autism Sutcliffe, James Vanderbilt University
Vasopressin receptors and social attachment Young, Larry Emory University

Objective Cumulative Funding Table

IACC Strategic Plan Objectives 2008 2009 2010 2011 2012 Total
Identify genetic risk factors in at least 50% of people with ASD by 2014.

IACC Recommended Budget: $33,900,000 over 6 years
3.8
$37,043,410
83 projects

3.L.B
$49,905,587
79 projects

3.L.B
$34,432,884
60 projects

3.L.B
$25,383,346
59 projects

3.L.B
$23,041,231
74 projects

$169,806,458
3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.

Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.

Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.