|Project Title||Principal Investigator||Institution|
|The role of the Rett gene, chromosone 15Q11-Q13, other genes, and epigenetics||Beaudet, Arthur||Baylor College of Medicine|
|Studies of postmortem brain searching for epigenetic defects causing autism||Beaudet, Arthur||Baylor College of Medicine|
|Integrative genetic analysis of autistic brains||Arking, Dan||Johns Hopkins University School of Medicine|
|Autism and the insula: Genomic and neural circuits||Allman, John||California Institute of Technology|
|IACC Strategic Plan Objective||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014. |
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective. |
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.