|Project Title||Principal Investigator||Institution|
|Understanding glutamate signaling defects in autism spectrum disorders||Wang, Tao||Johns Hopkins University|
|Genetic basis of autism||Wigler, Michael||Cold Spring Harbor Laboratory|
|Genetic contributions to endophenotypes of autism||Wijsman, Ellen||University of Washington|
|Vasopressin receptors and social attachment||Young, Larry||Emory University|
|Central vasopressin receptors and affiliation||Young, Larry||Emory University|
|Genomic resources for identifying genes regulating social behavior||Young, Larry||Emory University|
|Mutation analysis of candidate genes derived from an autism protein interaction network in SSC autism samples||Zoghbi, Huda||Baylor College of Medicine|
|Identifying autism susceptibility genes by high-throughput chip resequencing||Zwick, Michael||Emory University|
|IACC Strategic Plan Objectives||2008||2009||2010||2011||2012||Total|
|Identify genetic risk factors in at least 50% of people with ASD by 2014.
IACC Recommended Budget: $33,900,000 over 6 years
|3.L.B. Funding: The recommended budget was met. Significantly more than the recommended minimum budget was allocated to projects specific to this objective.
Progress: Further work is needed to identify genetic risk factors in at least 50% of people. Currently, whole exome analysis predicts that a genetic risk factor can be identified for 20% of people; inclusion of CNV data might push this toward 30%.
Remaining Gaps, Needs, and Opportunities: The initial budget recommendation for this objective was made based on the assumption that GWAS studies would provide risk factor identification, but sequencing has proven more fruitful. Since this technique is more expensive, a higher budget will be required to meet the goal of 50%.