Strategic Plan Objective Detail
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Question 3: Short-term Objective C  

$8,033,454.00
Fiscal Year: 2009

Green dot: Objective has greater than or equal to the recommended funding.3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Download 2009 Question 3: Short-term Objective C projects (EXCEL)
Note: Initial Sort is by Principal Investigator. Sorting by other columns is available by clicking on the desired column header.
Project Title Principal Investigator Institution
Prenatal factors and risk of autism in a Finnish national birth cohort Brown, Alan New York State Psychiatric Institute
Genome-wide environment interaction study for autism: The SEED study Fallin, Margaret Danielle Johns Hopkins University
Environment, the perinatal epigenome, and risk for autism and related disorders Fallin, Margaret Danielle Johns Hopkins University
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Feinberg, Andrew Johns Hopkins University
Whole-genome sequencing for rare highly penetrant gene variants in schizophrenia Goldstein, David Duke University
The CHARGE Study: Childhood Autism Risks from Genetics and the Environment Hertz-Picciotto, Irva University of California, Davis
Discordant monozygotic twins as a model for genetic-environmental interaction in autism Kaufmann, Walter Kennedy Krieger Institute
Genetics and gene-environment interactions in a Korean epidemiological sample of autism Kim, Young Shin Yale University
Epigenetic marks as peripheral biomarkers of autism Warren, Stephen Emory University

Objective Cumulative Funding Table

IACC Strategic Plan Objective 2008 2009 2010 2011 2012 Total
Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene-environment research by 2011.

IACC Recommended Budget: $27,800,000 over 5 years
3.4
$4,703,867
4 projects

3.S.C
$8,033,454
9 projects

3.S.C
$4,824,779
8 projects

3.S.C
$5,714,408
10 projects

3.S.C
$3,626,803
9 projects

$26,903,311
3.S.C. Funding: The recommended budget was nearly met, but work still needs to continue on this objective.

Progress: The funding allocated to this area so far has primarily supported building infrastructure that can now be expanded to include more subjects, more data, and more analytical projects. Studies such as the MARBLES (Markers of Autism Risk in Babies Learning Early Signs) cohort study and the CHARGE (Childhood Autism Risks from Genetics and the Environment) study are included under this objective.

Remaining Gaps, Needs, and Opportunities: Continued benefit will be derived from past investments as these resources are expanded and pooled.