Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone  

Using cultured human neuronal and glial cells, the project will investigate the dose-dependent ability of opiate receptor agonists and antagonists to affect excitatory amino acid transporter 3 (EAAT3)-mediated cysteine uptake. Results will provide a mechanistic link between the gluten-free, casein-free diet (GF/CF), low dose naltrexone (LDN), and the metabolic pathway whose dysfunction underlies autism. Project Status
NEW

2009

Funder Autism Research Institute
Fiscal Year Funding $44,000.00
Project Number 2009-5
Principal Investigator Deth, Richard
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.
Federal or Private? Private
Institution Northeastern University School of Pharmacy
State/Country Massachusetts
Web Link 1 Modulation of neuronal cysteine uptake and redox status by morphine, gluten/casein-derived opiates and naltrexone (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Not available at this time. This functionality is experimental.