Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Architecture of myelinated axons linking frontal cortical areas  

This research project will pinpoint the structural factors that contribute to the enlargement of white matter in the prefrontal cortex in autism. Dr. Barbas' fellow will examine post-mortem tissue from autistic and control individuals for differences in axon density, axon size, myelination, and number of non-neuronal cells that surround axons ("glia"). A second goal of this project is to develop the use of non-invasive imaging of white matter so that future studies will not have to rely on post-mortem tissue. As a first step, the prefrontal pathways in rhesus monkeys will be mapped. These pathways will initially be scanned using non-invasive diffusion tensor imaging (DTI); subsequently, these pathways will be labeled via injections of tracers into the same brains. Information from both DTI and tracer injections will then be compared to help optimize non-invasive scanning and image analysis protocols for future use in humans. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $54,000.00
Project Number 2156
Principal Investigator Barbas, Helen
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Private
Institution Boston University
State/Country Massachusetts
Web Link 1 Architecture of myelinated axons linking frontal cortical areas (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Architecture of myelinated axons linking frontal cortical areas | $0.00 | 2010 | 2156
Architecture of myelinated axons linking frontal cortical areas | $54,000.00 | 2008 | 2156