Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Relation of sleep epileptiform discharges to insomnia and daytime behavior  

Children with autism spectrum disorders (ASD) are known to have a higher prevalence of epilepsy and sleep disturbances, which may affect daytime functioning. Interictal epileptiform discharges (IEDs) are patterns of abnormal brain activity associated with epilepsy which have also been found to be prevalent in people with ASDs. Whether IEDs are involved in sleep disturbance in children with ASD is unknown, and this proposed study is aimed at examining potential links between IEDs, sleep, and behavior. Researchers will test the hypothesis that IEDs during sleep may affect sleep patterns, contributing to the underlying sleep disturbance which may in turn result in behavioral problems. Dr. Barnes and colleagues will examine the prevalence of IEDs during sleep in a cohort of children with ASD. IEDs are measured by electroencephalography (EEG), which records electrical activity in the brain in a noninvasive manner. EEG and behavioral data will be used to examine the relationships between sleep IEDs, sleep disturbances, and daytime behavior in these children. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $60,000.00
Project Number 3689
Principal Investigator Barnes, Gregory
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism including seizures/epilepsy, sleep disorders and familial autoimmune disorders by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Private
Institution Vanderbilt University
State/Country Tennessee
Web Link 1 Relation of sleep epileptiform discharges to insomnia and daytime behavior (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Relation of sleep epileptiform discharges to insomnia and daytime behavior | $0.00 | 2010 | 3689
Relation of sleep epileptiform discharges to insomnia and daytime behavior | $60,000.00 | 2008 | 3689