Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The pathogenesis of autism: Maternal antibody exposure in the fetal brain  

There is abundant evidence that autism occurs in families with evidence of autoimmunity. There is also evidence that mothers of an autistic child may have antibodies that react with brain tissue and even evidence that these antibodies, when given to pregnant mice or pregnant monkeys, cause behaviors in the offspring analogous to aspects of autism spectrum disorders (ASD). The investigators will explore the role of maternal antibodies in ASD, identifying maternal sera with anti-brain antibodies, determining if these antibodies can cause brain pathology and neurologic abnormalities in mice exposed to them during pregnancy, characterizing the brain antigen(s) recognized by the antibodies, and assessing how frequently these antibodies are present in mothers of an autistic child. This group will also examine children born to mothers with particular maternal antibodies and examine the relationship between these circulating antibodies and autism behaviors in the children. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $0.00
Project Number 4741
Principal Investigator Diamond, Betty
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 2SA. Support at least four research projects to identify mechanisms of metabolic and/or immune system interactions with the central nervous system that may underlie the development of ASD during prenatal-postnatal life by 2010. IACC Funding Budget: $9,800,000 over 4 years.
Federal or Private? Private
Institution The Feinstein Institute for Medical Research
State/Country New York
Web Link 1 The pathogenesis of autism: Maternal antibody exposure in the fetal brain (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The pathogenesis of autism: Maternal antibody exposure in the fetal brain | $90,173.00 | 2010 | 4741
The pathogenesis of autism: Maternal antibody exposure in the fetal brain | $110,000.00 | 2008 | 4741