Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways (supplement)  

This is a supplement to a previously awarded grant with the same title. This grant provides support for an NIH Autism Center of Excellence (ACE). A growing body of evidence suggests that autism is a disorder of brain connectivity. This project will study the anatomic connectivity and microstructural abnormalities of the brain in autism by using diffusion tensor magnetic resonance imaging (DT-MRI or DTI) and diffusion tensor tracking (DTT). Microscopic structural changes in white matter pathways and the associated gray matter regions in 40 individually-matched pairs of adults (age18-35 yrs) and 30 individually-matched pairs of children (age 6-11 yrs) with and without autism will be measured. Those results will be correlated with behavioral measures to identify phenotypic links with abnormalities in the brain microstructure. The results of this project will provide a comprehensive understanding of brain microstructure and histopathology and will also provide critical insight into the structural outcome of the early disturbances in brain growth in autism. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $2.00
Project Number 3P50HD055748-03S1
Principal Investigator Conturo, Thomas
Received ARRA Funding? Yes
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective 2O. Not specific to Question 2 objectives
Federal or Private? Federal
Institution University of Pittsburgh
State/Country Pennsylvania
Web Link 1 ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways (supplement) (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways | $12.00 | 2009 | 5P50HD055748-03
ACE Center: Diffusion tensor MRI + histopathology of brain microstructure + fiber pathways | $25.00 | 2010 | 5P50HD055748-04