Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Genetics of serotonin in autism: Neurochemical and clinical  

This grant provides support for an NIH Autism Center of Excellence (ACE). Neurochemical, behavioral, and genetic evidence implicate serotonin dysfunction in autism, specifically in restricted and repetitive behaviors (RRBs). Recently described mutations in a serotonin transporter gene reveal a common pattern of elevated serotonin transporter activity and a phenotype of autism with RRBs or obsessive compulsive disorder. In this research project, twenty-five serotonin related genes will be studied in 250 ASD children rigorously screened using ACE and Autism Diagnostic Interview, Revised (ADI-R) criteria to determine association with autism, specifically for Insistence on Sameness (IS). Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $377,577.00
Project Number 5P50HD055751-03
Principal Investigator Cook, Edwin
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective 3O. Not specific to Question 3 objectives
Federal or Private? Federal
Institution University of Illinois at Chicago
State/Country Illinois
Web Link 1 ACE Center: Genetics of serotonin in autism: Neurochemical and clinical (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes | $382,540.00 | 2010 | 5P50HD055751-04