Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment  

This project tests the hypothesis that developmental exposure to environmental contaminants perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may affect the number and/or function of regulatory T cells in mice, which consequently increases autoreactive T cell-induced damage within the brains of exposed offspring and leads to an autistic phenotype in exposed individuals. Project Status
NEW

2009

Funder Department of Defense
Fiscal Year Funding $106,609.00
Project Number AR093526
Principal Investigator DeWitt, Jamie
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.
Federal or Private? Federal
Institution East Carolina University
State/Country North Carolina
Web Link 1 Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment | $0.00 | 2010 | AR093526