Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The role of the neurexin 1 gene in susceptibility to autism  

Neurexin 1 (NRXN1) was recently implicated as an autism susceptibility gene. The association is intriguing because it interacts with neuroligin-3 and SHANK3 (two other genes previously found to generate risk for autism and mental retardation) at synaptic junctions to help regulate synapse formation. Dr. Gusella and his colleagues plan to examine NRXN1 in samples from AGRE and samples collected by collaborators for mutations or variations that could disrupt its function and determine if it plays a role in a larger proportion of autism cases. In addition, since the samples will be clinically well characterized, there is also an opportunity to establish a more robust correlation between genetic variation and clinical presentation. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $0.00
Project Number 2042
Principal Investigator Gusella, James
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.
Federal or Private? Private
Institution Massachusetts General Hospital/Harvard Medical School
State/Country Massachusetts
Web Link 1 The role of the neurexin 1 gene in susceptibility to autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The role of the neurexin 1 gene in susceptibility to autism | $127,500.00 | 2010 | 2042
The role of the neurexin 1 gene in susceptibility to autism | $150,000.00 | 2008 | 2042