Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

ACE Center: Risk and protective factors in the development of associated symptoms in autism  

This grant provides support for an NIH Autism Center of Excellence (ACE). This project examines the interaction between genetic and child phenotypic risk factors and family processes in determining outcome in autism. Outcome will be examined not only in terms of core symptoms but also in terms of associated symptoms, including repetitive and stereotyped behaviors, hyperactivity, and externalizing and internalizing behaviors. First, in a prospective longitudinal cohort study of children who are transitioning into adolescence, the study will investigate the role of genetic, child phenotypic, and family risk and protective factors in development of associated symptoms. Second, in a younger longitudinal cohort, a follow-up study of a randomized, controlled trial of early intensive behavioral intervention to examine the long term effects on both core and associated symptoms will be conducted. The identification of risk and protective factors related to long term outcome, including the development of associated symptoms, will inform critical targets for therapeutic intervention for affected children and families. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $171,867.00
Project Number 5P50HD055782-03
Principal Investigator Estes, Annette
Received ARRA Funding? No
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 4SF. Launch five randomized controlled trials of interventions including biological signatures and other measures to predict response, and monitor quality of life and functional outcomes, in each of the following groups:
  • Five trials in infants and toddlers by 2013. IACC Recommended Budget: $30,000,000 over 5 years.
  • Three randomized controlled trials of interventions for school-aged children and/or adolescents by 2013. IACC Recommended Budget: $18,000,000 over 5 years.
  • Three trials for adults by 2014. IACC Recommended Budget: $18,000,000 over 5 years.
Federal or Private? Federal
Institution University of Washington
State/Country Washington
Web Link 1 ACE Center: Risk and protective factors in the development of associated symptoms in autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects ACE Center: Risk and protective factors in the development of associated symptoms in autism | $169,876.00 | 2010 | 5P50HD055782-04