Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Probing disrupted cortico-thalamic interactions in autism spectrum disorders  

Sensory information (such as vision, hearing, and touch) is transmitted through various stations in the brain as it is relayed to the cortex. This proposal tests a novel hypothesis that during development, the cortex sends information to guide the development of these stations. A feed-forward and feedback communication between different regions of the brain could result in the spreading of an initially focal abnormality. This could be the underlying cause of neurodevelopmental diseases such as Rett Syndrome and autism spectrum disorders (ASD). A mouse model of Rett syndrome (RTT) that has impaired development of visual function will be used to understand the developmental relationship between the thalamus and the cortex. A feed forward and feedback interaction between the central nervous system (CNS) structures would mean that defects in one area could affect the other and amplify over time or that changes in one structure can compensate for defects in the other. Thus, a deeper understanding of the developmental relationship between the thalamus and cortex could have implications in neurodevelopment disorders such as ASD. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $518,375.00
Project Number 1R01NS070300-01
Principal Investigator Fagiolini, Michela
Received ARRA Funding? Yes
Strategic Plan Question Question 4: Which Treatments And Interventions Will Help? (Interventions)
Strategic Plan Objective Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.
Federal or Private? Federal
Institution Children's Hospital Boston
State/Country Massachusetts
Web Link 1 Probing disrupted cortico-thalamic interactions in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Probing disrupted cortico-thalamic interactions in autism spectrum disorders | $531,624.00 | 2010 | 5R01NS070300-02