Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Language functioning in optimal outcome children with a history of autism  

Prognosis for children with autism spectrum disorder (ASD) receiving intensive early intervention has improved substantially. A minority of these children appear to reach what may be called "optimal outcome," in which cognitive and adaptive functioning are within normal limits, and they no longer meet criteria for any ASD. While these optimal outcome children regain many normal language functions, preliminary studies show that some language impairments persist. These preliminary results raise the question: what are the underlying neural mechanisms of the striking improvement of cognitive processes in these optimal outcome children? Functional magnetic resonance imaging (fMRI) will be used during tasks of syntax and face processing to address this question, and exploratory analysis of selected structural variables will be examined to see if the most successful intervention appears to operate on a structurally normal brain. Project Status
ONGOING

2009

Funder National Institutes of Health
Fiscal Year Funding $457,153.00
Project Number 5R01MH076189-04
Principal Investigator Fein, Deborah
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Green dot: Objective has greater than or equal to the recommended funding. 2LB. Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC Recommended Budget: $7,200,000 over 5 years.
Federal or Private? Federal
Institution University of Connecticut
State/Country Connecticut
Web Link 1 Language functioning in optimal outcome children with a history of autism (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Language functioning in optimal outcome children with a history of autism | $489,612.00 | 2008 | R01MH076189-03