Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure  

This project will investigate the role of three separate factors in an animal model of autism spectrum disorder: a) genetic susceptibility, b) hormonal environment, and c) possible environmental triggers. A mouse model with a mutation of the reelin gene, implicated in autism spectrum disorders, will be studied after exposure to methyl and ethyl mercury. Both behaviors and neuropathological endpoints will be explored. Finally, the role of endogenous sex hormones will be examined by eliminating the testosterone "surge" around the time of puberty. The individual effects of each will be examined as well as the interaction of the three components (genetic liability, environmental exposure, hormonal influences) to determine gene x environment interactions. This study will use a unique design to study multiple factors in the etiology of autism spectrum disorder in a mouse model, isolating and combining factors which previously have been implicated in the pathophysiology and behavioral phenotype. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $92,582.00
Project Number 4919
Principal Investigator Keller, Flavio
Received ARRA Funding? No
Strategic Plan Question Question 3: What Caused This To Happen And Can This Be Prevented? (Risk Factors)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3LC. Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.
Federal or Private? Private
Institution Universita Campus Bio-Medico di Roma
State/Country Italy
Web Link 1 Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | $92,582.00 | 2010 | 4919
Analysis of developmental interactions between reelin haploinsufficiency, male sex, and mercury exposure | $110,000.00 | 2008 | 4919