Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders  

In the present study, researchers will test the hypothesis that early changes in brain growth in autism has long-term consequences for neural connectivity, or communication between different regions of the brain, as changes in connectivity are thought to underlie the symptoms of autism. Dr. Kleinhans and colleagues will examine this proposed relationship between early brain growth and later brain connectivity. They will gather previously collected measurements of brain size and volume from 3 to 5 year old children with low-functioning autism. When these children are 15 years old, they will be asked to participate in a brain imaging study using functional magnetic resonance imaging (fMRI), a non-invasive method of imaging patterns of brain activity and neural connectivity. These data should determine whether an increase in brain size during childhood is correlated with weakened or changed patterns of connections between brain regions in teenagers with autism and contribute to the understanding of the developmental basis of behavioral impairment and clinical outcomes in autism spectrum disorders. Project Status
ONGOING

2009

Funder Autism Speaks
Fiscal Year Funding $124,816.00
Project Number 3628
Principal Investigator Kleinhans, Natalia
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.
Federal or Private? Private
Institution University of Washington
State/Country Washington
Web Link 1 Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | $103,062.00 | 2010 | 3628
Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | $120,000.00 | 2008 | 3628