Project Detail
Interagency Autism Coordinating Committee (IACC) logo
Office of Autism Research Coordination (OARC) logo

The microRNA pathway in translational regulation of neuronal development  

Several mental disorders are closely associated with defects during neuronal development in early life. Abnormalities in neuronal differentiation and synaptogenesis may contribute to fragile X syndrome, Rett syndrome, autism, and other mental disorders. Post-transcriptional regulation by tiny RNAs, called microRNAs (miRNAs), has emerged as an important mechanism for controlling gene expression in animal development; however, the exact functions of miRNAs in neuronal differentiation and function are poorly understood. In this proposal, investigators will use fruit flies to study the roles of microRNAs in the development of the nervous system. The proposed studies will provide important novel insights into the neuronal functions of the miRNA pathway in intact animal models and will further understanding of human mental disorders. These findings may also help develop new avenues for therapeutic interventions for these devastating illnesses. Project Status
NEW

2009

Funder National Institutes of Health
Fiscal Year Funding $417,813.00
Project Number 9R01NS066586-06A2
Principal Investigator Gao, Fen-Biao
Received ARRA Funding? No
Strategic Plan Question Question 2: How Can I Understand What Is Happening? (Biology)
Strategic Plan Objective New! Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.
Federal or Private? Federal
Institution J. David Gladstone Institutes
State/Country California
Web Link 1 The microRNA pathway in translational regulation of neuronal development (External web link)
Web Link 2 No URL available.
Web Link 3 No URL available.
New! History/Related Projects The microRNA pathway in translational regulation of neuronal development | $37,604.00 | 2010 | 5R01NS066586-07
The microRNA pathway in translational regulation of neuronal development | $376,031.00 | 2010 | 7R01NS066586-08